Q. The adb file has been trashed! What happened and how do I fix it???
A. Likely another application or ASP file has opened the file via the OCX and then died, locking out the file. Or perhaps it has been opened by another application directly for writing, thereby locking everyone else out.
To avoid a reboot when restoring your backup copy of the adb file:
Stop IISAdmin (not just IIS), the Windows GUI, and any other software using the product (including the event viewer if you have it open).
Then replace, then restart the services.
See also "SaveLockMuteX Failed"